Animal experiment demonstrates antidiarrheal and antibacterial activity of Cordia dichotoma in Wistar rats, indicating potential gastrointestinal therapeutic benefits.
activities of the hydro-alcoholic extract of Cordia dichotoma leaves (CD). The CD was screened on the dose-response curve (DRC) of acetylcholine (Ach) over isolated ileum. CD was evaluated in the model (n=6), including Group I received 0.1% Carboxymethyl cellulose@1ml/100g b.wt., Group II, Loperamide@2.5mg/Kg b.wt., Group III, IV, and V, had CD@125, 250, and 500mg/Kg respectively. The CD was also screened for its antibacterial effects over Escherichia coli and Staphylococcus aureus.CD shifted the DRC of Ach towards the right, showed a dose-dependent decline in diarrhea, and had antibacterial activities over E. coli.
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Dev et al. (2024) studied this question.
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