We encapsulated silver nanoplates (AgNPLs) into poly(lactic-co-glycolic) acid (PLGA) nanoparticles. The encapsulation stabilized the AgNPLs in a physiological environment and the antibacterial activity of the AgNPLs against planktonic bacteria was reduced. However, the PLGA nanoparticles encapsulating the AgNPLs were internalized into macrophages and showed antibacterial activity against intracellular bacteria. AgNPL-loaded PLGA nanoparticles are promising for treating intractable infectious diseases caused by bacteria-infecting macrophages.
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Nawata et al. (2024) studied this question.
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