D-41 | Assessing the Burden of Frailty in Chronic Total Occlusion Interventions: In-Hospital Mortality and Readmission Outcomes Post-PCI

Frailty poses significant risks for adverse health outcomes, particularly in complex medical procedures. The implications of frailty in patients receiving percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) are increasingly relevant yet insufficiently understood, especially concerning in-hospital outcomes. Utilizing the National Readmission Database (NRD) from 2016 to 2020, this study focused on patients undergoing PCI for chronic total occlusions (CTO). Patients were categorized into low and high-frailty risk groups using the Hospital Frailty Risk Score (HFRS). The primary analysis centered on 30-day readmission rates post-CTO PCI. Baseline characteristics are detailed in Table I. Our analysis revealed significant differences in 30-day readmission rates between frail and non-frail patients (19.6% vs. 7.1%, P = 0.005), as illustrated by the Kaplan-Meier Curve. In-hospital mortality was higher in frail patients (2.1%) than non-frail patients (0.7%, P = 0.2916), with details of other secondary outcomes presented in Table II. The overall readmission rate for the CTO cohort was 18.9%, emphasizing frailty's impact on these outcomes. This study highlights the significant influence of frailty on in-hospital outcomes for patients undergoing PCI for CTO. Frail patients face notably higher risks of 30-day readmission and in-hospital mortality compared to non-frail patients. These results underscore the importance of developing specialized care strategies and interventions for frail patients to enhance outcomes and ensure quality care in this vulnerable group.