Frailty, often linked with aging, markedly impacts physiological resilience and influences outcomes in complex medical procedures. This study investigates frailty's effects on in-hospital mortality and readmission post-percutaneous coronary intervention (PCI) in chronic total occlusions (CTO). Analyzing the National Readmission Database (NRD) from 2016 to 2020, we focused on patients undergoing CTO PCI. Using the Hospital Frailty Risk Score (HFRS), patients were categorized into low and high-frailty risk groups. Primary outcomes included in-hospital mortality, and secondary outcomes comprised 30-day readmission rates, Major Adverse Cardiovascular Events (MACE), Acute Kidney Injury, hospital stay length, and costs. Table I shows baseline characteristics. Analysis revealed significant 30-day readmission rate differences between frail (19.6%) and non-frail patients (7.1%, P = 0.005). In-hospital mortality was higher in the frail group (2.1%) compared to non-frail patients (0.7%, P = 0.2916). Other outcomes are detailed in Table II. This study emphasizes frailty's critical role in in-hospital outcomes post-CTO PCI. Frail patients face higher readmission risks, emphasizing the need for specialized care strategies, including rehabilitation, to enhance outcomes in this vulnerable group.
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Bolaji et al. (2024) studied this question.
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