B-28 | Iodinated Contrast Use in Coronary Angiography and Incidence of Thyroid Abnormalities

Excess iodine intake has been associated with increased incidence of thyroid dysfunction and small studies have shown increased incidence of thyroid dysfunction (TD) in patients undergoing contrasted radiographic studies. However, little is known about thyroid abnormalities following coronary angiography and percutaneous coronary interventions (PCI). This study aimed to determine the incidence and risk of thyroid dysfunction by contrast volume following angiography. Through retrospective analysis of electronic health records data, we identified adult patients undergoing first known coronary angiography between 4/4/2014 and 6/26/2022. Patients were divided into 4 groups (1: <100 ml, 2: 100-199 ml, 3: 200-299 ml, 4: >300 ml) based on total amount of contrast administered in the initial and any subsequent cardiac catheterization within 1 year from the first procedure or prior to a diagnosis of thyroid dysfunction. ICD 10 codes were then used to identify incidence of thyroid dysfunction in these patients within 1 year of their intervention. The total cohort included 27,740 patients undergoing diagnostic coronary angiography with or without intervention. Among 6,760 patients in group 1, 3.18% (n=215) of patients received a diagnosis of TD. Of these, 0.43% were diagnosed with hyperthyroidism, and 2.59% with hypothyroidism. Among 12,852 group 2 patients, 3.02% (n=388) received a diagnosis of TD (0.29% hyperthyroid, 2.45% hypothyroid). Among 5,065 group 3 patients, 3.47% (n= 176) were diagnosed with TD (0.30% hyperthyroid, 2.86% hypothyroid). In group 4, the highest contrast group with 3,063 patients, 3.13% (n= 96) were diagnosed with thyroid dysfunction 0.42% hyperthyroid, 2.35% hypothyroid). There was no significant increase in thyroid dysfunction with increasing contrast volume (p>0.05). In our study, the volume of contrast used during coronary angiography and PCI was not associated with higher incidence of abnormal thyroid diagnoses.