A-61 | Cardiovascular Risk Factors in A Population With Autoimmune Hepatitis: A Nationwide Retrospective Cohort Study

Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver characterized by periportal inflammation, hypergammaglobulinemia, and anti-smooth muscle autoantibodies. Cardiovascular disease has been previously hypothesized to be present in patients with autoimmune hepatitis given cytokine release, chronic inflammation, and chronic immunosuppressant use, occurring at a younger age than in individuals without AIH. Our study aims to show the characteristics of patients with AIH and cardiovascular disease. We utilized the Nationwide Inpatient Sample Database, a large all-payer inpatient database in the United States, to gather all patients with a primary diagnosis of AIH and queried their cardiovascular risk factors. There were 28,729 patients with AIH. Obesity prevalence was higher among groups from 18-64 years of age, declining in patients above 64 years old. The remainder of cardiovascular comorbidities trended toward an increased prevalence with increasing age. There is a significant presence of cardiovascular disease and risk factors in patients with AIH that predominately affect an older population. Further studies should be performed to evaluate if different preventative cardiovascular disease screenings or interventions should be performed for this special population.