D-26 | Impact of Gender on Outcomes of Cardiogenic Shock Patients with Hypertrophic Obstructive Cardiomyopathy

Management guidelines for hypertrophic obstructive cardiomyopathy (HOCM) do not currently account for the impact of gender. As cardiogenic shock (CS) patients tend to have unfavorable prognosis, we aimed to assess the impact of gender on outcomes among CS patients admitted with HOCM (HOCM-CS). From the Nationwide Inpatient Sample (2016-19), we extracted data on all CS patients (ICD 10: R570) with an underlying diagnosis of HOCM (I421, I422). In-hospital outcomes like mortality, stroke and acute kidney injury were compared between males and females. A total of 4,165 HOCM-CS patients were included in the present study among which 2,050 (49.2%) were males and 2,115 (50.8%) were females. In general, females were older than males (mean age, 65 vs. 58 years) with a higher prevalence of hypertension, chronic pulmonary disease, pulmonary hypertension and hypothyroidism (Table 1). Male patients had a higher incidence of prior stroke, and alcohol and drug abuse. In-hospital mortality was significantly higher among female HOCM-CS patients (29.1% vs. 23.4% for males, p<0.001). Conversely, male patients suffered stroke (4.6% vs. 3.3%) and acute kidney injury (70.2% vs. 53.7%) more frequently than females. HOCM-CS is associated with poor outcomes in general, and has a gender predilection with worse mortality rates among females. Society guidelines may need to include gender as a potential player in the management and prognosis of HOCM patients with underlying CS.