Primary adrenal insufficiency (PAI) is a rare clinical disorder with an insidious onset characterized by a decreased production of glucocorticoids and associated with potentially life-threatening complications. The clinical presentation is non-specific with features including fatigue, weight loss, hypoglycemia, muscle weakness and abdominal pain. Most cases are caused by autoimmune adrenalitis which can be isolated or occur as part of an autoimmune polyendocrinopathy syndrome. Other causes of PAI include adrenal hemorrhage, infiltrative disorders, metastasis, and infection.
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Fernando et al. (2024) studied this question.
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