Cushing's syndrome is a rare, life-threatening endocrine disorder due to excess cortisol from either an adrenocorticotropic hormone (ACTH)-independent or ACTH-dependent source. Endogenous Cushing's syndrome due to ACTH-secreting pheochromocytomas remains a diagnostic and therapeutic challenge due to the additive effects of both cortisol and catecholamine excess. Given its rarity, there are limited studies on its diagnosis, management, and outcomes. Here, we present a complicated case of severe Cushing's syndrome due to an ectopic ACTH-secreting pheochromocytoma with severe thrombocytopenia.
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Nguyen et al. (2024) studied this question.
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