Historically, bilateral adrenal gland destruction by tuberculosis (TB) was the most common cause of primary adrenal insufficiency. However, its incidence has significantly decreased in the developed world, where autoimmune adrenal insufficiency now constitutes most reported cases, ranging from 70-90%. Adrenal tuberculosis typically arises after pulmonary or genitourinary TB, although rare instances manifest as isolated TB.
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Melendez-Rivera et al. (2024) studied this question.
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