Selective Organ‐Targeting Hafnium Oxide Nanoparticles with Multienzyme‐Mimetic Activities Attenuate Radiation‐Induced Tissue Damage (Adv. Mater. 19/2024)

Organ-Targeting Radioprotective Nanozymes Unlike commonly known radioenhancing similars, rationally designed HfO2 nanoparticles herein are surprisingly radioprotective and capable of selectively targeting top vulnerable normal organs to counteract off-target toxicity during radiotherapy. Under CT image guidance, the multienzyme-mimetic agents can alleviate DNA damage and inflammation in mouse and rabbit models upon hazardous radiation exposure, resulting in prolonged survival. More details can be found in article number 2308098 by Weijun Fan, Jiang Yang, and co-workers.