Multimodal radiosensitization by Hafnium Oxide Nanoparticles and HDAC inhibitors: mechanistic insights

January 1, 2026Nanoscale AdvancesOpen Access

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Key Points

The aim is to explore how hafnium oxide nanoparticles and HDAC inhibitors work together to enhance radiosensitivity in cancer cells.
Utilized in vitro models to assess the effects of hafnium oxide nanoparticles and HDAC inhibitors during radiation exposure.
Measured cell viability and DNA damage to evaluate radiosensitization effects.
Conducted mechanistic studies to understand how these agents enhance radiation effects.
Hafnium oxide nanoparticles significantly increased the radiosensitivity of cancer cells.
Combined treatment with HDAC inhibitors further enhanced this effect.
Mechanistic insights revealed increased DNA damage and altered cellular responses to radiation.

Demonstrates enhanced radiosensitization using hafnium oxide and HDAC inhibitors, suggesting improved treatment strategies for cancer.

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Bocz et al. (2026) studied this question.

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