D150. Gender Affirming Surgery and Reduced Rates of Psychiatric Co-morbidities in Patients with Gender Dysphoria

PURPOSE: Limited data exists regarding the prevalence of psychiatric co-morbidities in patient with gender dysphoria (GD) who have undergone genital reconstruction for gender affirmation (GRGA). This study aimed to investigate rates of psychiatric co-morbidities in patients with GD who have undergone GRGA. METHODS: We conducted a cross-sectional analysis using TriNetX, a healthcare database with >250 million patients. Using CPT and ICD-10 codes, we identified and compared psychiatric co-morbidity rates in two cohorts: 1) patients with GD without GRGA, 2) patients with GD with GRGA. Patients were matched according to age, biological sex, race/ethnicity, and common health co-morbidities. RESULTS: We identified 3,940 patients with a history of GD with GRGA and 98,697 patients with a history of GD without GRGA. In the GD with GRGA cohort, the mean age was 36.3, 56.9% were female, and the predominant race was white. In the GD without GRGA cohort, the mean age was 37.0, 57.2% were female, and the predominant race was white. Relative to GD without GRGA cohort, the GD with GRGA cohort had significantly lower rates of depression (OR 0.807, p=0.0007), anxiety disorders (OR 0.844, p=0.0007), substance use disorder (OR 0.765, p=0.0038), and suicidality (OR 0.089, p<0.0001). There was no significant difference in post-traumatic stress disorder rates (p=0.3302). CONCLUSION: Our study illustrates that patients with GD who have undergone GRGA have reduced psychiatric co-morbidities. These findings provide valuable insights for providers, enabling them to develop targeted interventions and support systems to enhance the mental health outcomes of individuals with GD.