Evaluation of Radiomic Analysis over the Comparison of Machine Learning Approach and Radiomic Risk Score on Glioblastoma

Accurate patient prognosis is important to provide an effective treatment plan for Glioblastoma (GBM) patients. Radiomics analysis extracts quantitative features from medical images. Such features can be used to build models to support medical decisions for diagnosis, prognosis, and therapeutic response. The progress of radiomics analysis is continuously improving. The aim of this research is to extract standardised radiomic features from MRI scans of GBM patients, perform feature selection, and compare radiomic-based risk score (RRS) and machine learning (ML) approaches for the risk stratification of GBM patients. We have also tested the generalisability of these models which is crucial for clinical implementation. Our work demonstrates that a stratification model based on logistic regression generalised better than the RRS method when applied to new unseen datasets.