Benign Macrocystic Serous Cystadenoma of the Tail of the Pancreas: A Case Report

Serous cystadenoma is a rare benign cystic lesion of the pancreas, predominantly affecting women with a mean age of onset around 62 years. While often asymptomatic, it can manifest with nonspecific symptoms such as abdominal pain and nausea. We present the case of a 68-year-old woman with abdominal pain and nausea, diagnosed with a serous cystadenoma in the tail of the pancreas through imaging modalities. Radiological examinations revealed a septated, multilayered cystic lesion with lobulated contour and calcifications. Surgical resection was performed, and pathological examination confirmed a serous cystadenoma. Differential diagnosis from pseudocysts and malignant serous cystadenocarcinomas is crucial. Treatment options include pancreatic resection, with close monitoring recommended for asymptomatic patients or those at high surgical risk. Despite their benign nature, accurate diagnosis and management of serous cystadenomas are essential.