Cover Feature: Sulfoxide‐Mediated Cys‐Trp‐Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization (ChemistryEurope 3‐4/2024)

This is the authors' abstract. We don't add key points for this paper.

A tryptophan modification that utilizes S-acetamidomethyl cysteine sulfoxide under mildly acidic conditions with magnesium chloride was achieved. An optimum condition in an ionic liquid allowed antibody modification without significant denaturation. In their Research Article, A. Otaka and co-workers describe the difference in chemical behaviors to acids between S-acetamidomethyl and p-methoxybenzyl cysteine sulfoxides permitted peptide heterodimerization in a one-pot sequential manner.