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Background: A considerable blood loss risk is linked with major orthopaedic surgeries.Transfusions of red blood cells avoid these problems, although they carry a risk of their own.Tranexamic acid prevents plasmin from dissolving and breaking down fibrin clots.This research aims to evaluate the efficacy of intravenous infusion of prophylactic dosages of tranexamic acid (10 mg/kg) vs 20 mg/kg) one hour before orthopaedic surgery to compare two different prophylactic tranexamic acid doses' impact on patients undergoing orthopaedic surgeries.Methods: The study was a parallel group interventional randomised control experiment.Sixty ASA 1 and ASA 2 patients formed 2 groups; Group A received an injection of tranexamic acid 10 mg/kg in 100 ml NS, while Group B received 20 mg/kg in 100 ml NS one hour before surgery.Postoperative drain collection was seen in the sixth, twelve, and twenty-four hours.Differences in Hb before and after surgery were observed.Results: Age, sex, body weight, length of operation, and amount of intravenous fluid transfusion did not differ statistically significantly across the groups.Both groups had a statistically significant difference in Hb between pre-and post-op.Group A's mean difference in Hb levels revealed noticeably lower values.Group A required a lot more blood transfusions than the other group.Conclusion: Higher doses of tranexamic acid (20 mg/kg bolus) used prophylactically are inexpensive, safe, and effective ways to lower intraoperative blood loss and, thus, the need for postoperative blood transfusions.
Acharya et al. (Wed,) studied this question.