Abstract 1140: Contrast-induced Nephropathy Among Hospitalized Patients With Chronic Limb Threatening Ischemia Undergoing Percutaneous Transluminal Angioplasty - A Nationwide Analysis

Introduction: Among patients with chronic limb-threatening ischemia (CTLI) who are not responsive to lifestyle changes and pharmacotherapy, surgical or endovascular treatment are indicated. Contrast-induced nephropathy (CIN) is a known complication of endovascular interventions. In this study, we examine the prevalence of CIN among hospitalized patients with CTLI undergoing percutaneous transluminal angioplasty (PTA). Methods: Using the International Classification of Diseases, 10th edition, Clinical Modification (ICD-10-CM) diagnosis and procedure codes, we queried the National Inpatient Sample 2016 to 2020 for hospitalizations among patients ≥18 years old with a diagnosis of contrast-induced nephropathy and chronic limb-threatening ischemia and a procedure code for lower extremity PTA. We identified the prevalence of CIN among patients with CTLI undergoing endovascular treatment. Sociodemographic differences were examined among patients with CTLI undergoing PTA with and without CIN. Results: Our study included 500,690 weighted hospitalizations with CTLI, of which 57,020 (11.4%) underwent PTA. CIN was observed among 690 (1.2%) of patients with CTLI and was more common among males compared to females (53.6% vs. 46.4%) Patients with CIN were older compared to those without CIN (mean [SD] age: 70.7 [11.9] vs 68.8 [11.8] years, p=0.06 ). Among hospitalizations for CTLI who underwent PTA, the proportion of patients with CIN was higher than those without CIN for Blacks (28.4% vs. 21.1%) and Hispanics (14.2% vs. 13.2%) but not for Whites (53.0% vs. 60.1%) and Asian/Pacific Islanders (0.8% vs. 1.4%) ( p=0.4 ). CIN was more common among those with Medicaid (65.2%) compared to those with private insurance (17.4%), Medicare (10.1%), and self-pay (2.9%) ( p=0.4 ). Conclusion: Disparities exist in the prevalence of contrast-induced nephropathy among hospitalized patients with chronic limb-threatening ischemia undergoing percutaneous transluminal angioplasty. Results could be used to support future research to examine factors driving these disparities.