Bullous fixed drug eruption due to azithromycin: A rare case report

Fixed drug eruption (FDE) is a common type of cutaneous adverse drug reaction. It is a delayed type of hypersensitivity reaction that occurs and recurs as lesions at the same skin site due to repeated intake of an offending drug. Drugs such as ciprofloxacin, acetaminophen, fluconazole, nimesulide, sulfonamides, tetracyclines, and metronidazole have been reported to cause the bullous form of FDE. FDE due to azithromycin have been reported, but the bullous variant is extremely rare. We present a case of azithromycin-induced bullous FDE in a 32-year-old male. Data were collected through a patient history and clinical examination during consultation. The patient developed a tense bullous lesion on the lower lip after taking azithromycin for an upper respiratory tract infection. This case highlights the importance of recognizing rare adverse reactions to commonly prescribed antibiotics like azithromycin.