Medicinal chemistry study reveals novel isoalantolactone derivatives targeting the NLRP3 inflammasome, highlighting therapeutic potential for inflammatory diseases.
The NLRP3 inflammasome has been recognized as a promising therapeutic target in drug discovery for inflammatory diseases. Our initial research identified a natural sesquiterpene isoalantolactone (IAL) as the active scaffold targeting NLRP3 inflammasome. To improve its activity and metabolic stability, a total of 64 IAL derivatives were designed and synthesized. Among them, compound
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Zhao et al. (2024) studied this question.
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