April 30, 2024Journal of Affective DisordersOpen Access

The complexity of treatment-resistant depression: A data-driven approach

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Authors

FRFelicitas RostThe Tavistock and Portman NHS Foundation Trust TBThomas BookerThe Tavistock and Portman NHS Foundation Trust AGAneliya GonsardThe Tavistock and Portman NHS Foundation Trust

Discussion

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Implication

Randomized trial reveals high psychiatric and physical comorbidity in patients with treatment-resistant depression, highlighting the need to reconceptualize clinical care.

Key Points

Patients with treatment-resistant depression show a chronic course spanning over 25 years, marked by high psychiatric comorbidity and impaired quality of life.
Among 129 primary care participants, 82.9% had an additional psychiatric diagnosis alongside high rates of personality disorder and suicidal ideation.
Pragmatic randomized controlled trial data call for a broader clinical definition, though findings are limited by recall bias and the lack of a control group.

Cite This Study

Rost et al. (2024) studied this question.

synapsesocial.com/papers/68e6ca92b6db64358764900b https://doi.org/10.1016/j.jad.2024.04.093

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Implication

Randomized trial reveals high psychiatric and physical comorbidity in patients with treatment-resistant depression, highlighting the need to reconceptualize clinical care.

The complexity of treatment-resistant depression: A data-driven approach

Discussion

Member takes

Implication

Key Points

Cite This Study

The complexity of treatment-resistant depression: A data-driven approach

Discussion

Member takes

Implication

Key Points

Cite This Study

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