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April 30, 2024Cell Communication and SignalingOpen Access

Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling

Lap Hing Andrew Redfern Suraya Roslan Ian P. Street Allan D. Burrows Robin L. Anderson

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Abstract

Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive.

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Cite This Study

Hing et al. (2024) studied this question.

synapsesocial.com/papers/68e6cbe0b6db643587649679 https://doi.org/10.1186/s12964-024-01559-0

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