Evaluation of a Polyherbal Formulation in Experimentally Induced Asthma in Sprague Dawley Rats

Asthma is defined as an airway hyperresponsiveness which is basically brought on by chronic inflammation which causes repeated events of wheeziness, breathless-ness, stiffness in chest, and/or coughing that might change over time and it's concentration might also change with time.Various epidemiological study it is found that asthma is one the utmost widespread long-lasting disease with high morbidity and low mortality rate.There are various medications for the treatment; leukotriene modifiers, corticosteroids, β adrenergic agonists, anti-cholinergics, and others, but these give us just symptomatic effects and these also have various side or adverse effects.Whereas, variety of medications from, various plant sources have been studied for their potential anti-asthmatic properties in the course of past periods of years with little to no adverse effects.The target of the investigation is to show the efficacy of Polyherbal formulation acting through different mechanism of action and show its effect on experimentally induced asthma.Here, Grouping of 5 which 6 animal (Sprague Dawley Rat) in each group, i.e.Normal Control, Disease Control, Standard Control, Low Dose of Polyherbal formulation and High Dose of Polyherbal formulation based on Acute Oral Toxicity.From this study, it is observed that low dose of Polyherbal Formulation in comparison to Standard Control (Montelukast sodium) is showing better efficacy by detection of various biochemical parameters and histopathological parameters of every group.