One new cyclonerane sesquiterpene, 9,11-cycloneren-3,7-diol (1), along with four known ones, 11cycloneren-3,7,10-triol (2), 9-cycloneren-3,7,11-triol (3), 11-methoxy-9-cycloneren-3,7-diol (4), and cyclonerodiol (5), were obtained from the extract of marine-derived fungus Trichoderma harzianum WH-22.The structure of 9,11-cycloneren-3,7-diol (1) was elucidated by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS data.9,11-Cycloneren-3,7-diol (1) exhibited weak cytotoxicity against HeLa and HepG2 cancer cell lines with IC50 values of 68.2 and 59.7 μM, respectively.
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Liu et al. (2024) studied this question.
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