Diagnostic accuracy of estimated glomerular filtration rate in pediatric oncology patients.

Objective: To compare eGFR using different equations with 24-hour creatinine clearance Methodology: We collected data of standardized 24-hour creatinine clearance of pediatric oncology patients for a period of one year and compared the efficiency of various equations for estimation of creatinine clearance with it. For error estimation we used mean relative prediction error (MRPE) and root mean square error (RMSE) and for accuracy estimation we used Lin’s correlation. Results: Out of 100 study participants, 57 were males and 43 were females. Mean age of the population studied was 11.8 while mean BMI was 13.95. Most common tumor reported was osteosarcoma. Out of 18 equations evaluated only 5 showed an accuracy of 0.80 or more, while SEM of none of the equation is near to the desired value (zero). Minimum SEM was found to be for Schwartz (2012) equation. Conclusions: According to our study none of the equations in current clinical practices showed a good correlation with creatinine clearance adjusted according to body surface area.