Clinical complexity unveiled: A case of primary biliary cholangitis autoimmune hepatitis overlap syndrome

Overlap syndrome with primary biliary cholangitis and autoimmune hepatitis (PBC-AIH) remain uncommon liver autoimmune-related disorders. Diagnosis is based on clinical, biochemical, serological, and histological findings. Early diagnosis of the disease will give the best outcome even though evidence-proven treatment is still unavailable to tackle this disease entity. Here, we present a case of a Sri Lankan woman diagnosed with PBC-AIH overlap syndrome. She presented with symptoms of jaundice and pruritus. Extensive investigations, including liver biopsy were instrumental in confirming the diagnosis.