The development of insulin resistance and diabetes in obese people is caused by metabolic inflammation. In adipose tissues in the abdomen, macrophages infiltrate and cause insulin resistance. As a result of the macrophages adopting an M1 polarization, pro-inflammatory cytokines are released. Piperine, known for its potent anti-inflammatory properties, is being studied as a potential treatment for inflammatory diseases. Our findings suggest that piperine, an immunomodulator, can effectively treat obesity-related diabetes.
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Balaji et al. (2024) studied this question.
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