Comparative Analysis of Some Biochemical Blood Parameters in Opisthrochisis

Biochemical blood parameters were analyzed in the chronic phase of opisthorchiasis in rabbits in an experiment for the first time. Sexually mature males were infected with 50 Opisthorchis felineus (Rivolta, 1884) metacercariae isolated from the muscle tissue of Leuciscus leuciscus per one animal (n = 10). After confirmation of occurred invasion in the animals, serum was examined at 61 months (about 5 years). Glucose, urea, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were determined in serum using a hematological analyzer. Own data obtained in the acute phase of opisthorchiasis at 1.5 months after infection were used as test and control. We found that glucose corresponded to normal values in the chronic phase as compared to the acute phase, and the data were statistically significant. Urea was normal as compared to the acute phase, and the data were statistically significant. AST level was within normal range and ALT was above normal values as compared to the acute phase. The data for liver enzymes among the invasion periods were not statistically significant. Thus, the studied biochemical parameters returned to normal in the chronic phase of opisthorchiasis compared to the acute phase except for ALT.