Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

Francesca Lupo; Francesco Pezzini; Davide Pasini; Elena Fiorini; Annalisa Adamo; Lisa Veghini; Michele Bevere; Cristina Frusteri; Pietro Delfino; Sabrina D’Agosto; Silvia Andreani; Geny Piro; Antonia Malinova; Tian Wang; Francesco De Sanctis; Rita T. Lawlor; Chang‐Il Hwang; Carmine Carbone; Ivano Amelio; Peter J. Bailey; Vincenzo Bronte; David A. Tuveson; Aldo Scarpa; Stefano Ugel; Vincenzo Corbo

doi:10.1136/gutjnl-2023-329807

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Abstract

The dysregulation of the axon guidance pathway is common in pancreatic ductal adenocarcinoma (PDAC), yet our understanding of its biological relevance is limited. Here, we investigated the functional role of the axon guidance cue SEMA3A in supporting PDAC progression.

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Lupo et al. (2024) studied this question.

synapsesocial.com/papers/68e6d587b6db643587652b04 https://doi.org/10.1136/gutjnl-2023-329807

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Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

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Abstract

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Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

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Abstract

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