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April 26, 2024BiochemistryOpen Access

Inositol Hexaphosphate as an Inhibitor and Potential Regulator of p47phox Membrane Anchoring

Angela M. Develin Brian Fuglestad

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Abstract

As a key component for NADPH oxidase 2 (NOX2) activation, the peripheral membrane protein p47

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Develin et al. (2024) studied this question.

synapsesocial.com/papers/68e6d6c0b6db64358765390d https://doi.org/10.1021/acs.biochem.4c00117

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abstract 1117 Insights into p47phox Regulation and Inhibition: A Membrane Anchor of NADPH Oxidase 22024
2Atypical Membrane-embedded Phosphatidylinositol 3,4-Bisphosphate (PI(3,4)P2)-binding Site on p47 Phox Homology (PX) Domain Revealed by NMROriginal Research · 2012 · 24 citations
3Point Mutations in the Proline-rich Region of p22 Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen GenerationOriginal Research · 2005 · 232 citations
4The NADPH oxidase 2 subunit p47phox binds to the WAVE regulatory complex and p22phox in a mutually exclusive manner2024 · 7 citations
5Opposing Roles of p47 <sup>phox</sup> in Basal Versus Angiotensin II–Stimulated Alterations in Vascular O <sub>2</sub> <sup>−</sup> Production, Vascular Tone, and Mitogen-Activated Protein Kinase Activationpreclinical · 2004 · 100 citations