March 2, 2004Circulation

Opposing Roles of p47 phox in Basal Versus Angiotensin II–Stimulated Alterations in Vascular O 2 − Production, Vascular Tone, and Mitogen-Activated Protein Kinase Activation

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Population

Aortae from p47phox-/- and matched wild-type (WT) mice (n=9/group)

Comparison

Ex vivo incubation with Angiotensin II vs Ex vivo incubation without Angiotensin II

Design

Preclinical

Follow-up

30 minutes

Authors

JLJian‐Mei LiArmy Medical University SWStephen B. WheatcroftLeeds General Infirmary LFLampson FanUniversity of Wolverhampton

Discussion

Member takes

Implication

p47phox may mediate Ang II-induced vascular dysfunction; hypothesis-generating for targeted NADPH oxidase inhibition in hypertension.

Structured PICO

Population

Aortae from p47phox-/- and matched wild-type (WT) mice (n=9/group)

Intervention

Ex vivo incubation with Angiotensin II (200 nmol/L, 30 minutes)

Comparator

Ex vivo incubation without Angiotensin II

Outcome

NADPH-dependent O2- production, endothelium-dependent and -independent vascular relaxation, and activation of mitogen-activated protein kinases (MAPKs)surrogate

The p47phox subunit plays a dual role by inhibiting basal NADPH oxidase activity while being essential for Angiotensin II-induced vascular dysfunction and oxidative stress.

Cite This Study

Li et al. (2004) studied this question.

synapsesocial.com/papers/6a712d6ae5469ee92be1c83c https://doi.org/10.1161/01.cir.0000118463.23388.b9

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Opposing Roles of p47 phox in Basal Versus Angiotensin II–Stimulated Alterations in Vascular O 2 − Production, Vascular Tone, and Mitogen-Activated Protein Kinase Activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Opposing Roles of p47 phox in Basal Versus Angiotensin II–Stimulated Alterations in Vascular O 2 − Production, Vascular Tone, and Mitogen-Activated Protein Kinase Activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider