Key result
Angiotensin II infusion in mice increased systolic blood pressure and aortic superoxide levels due to heightened adventitial NAD(P)H oxidase subunit expression, which was normalized by losartan.
Angiotensin II-induced increases in vascular superoxide are driven by heightened expression of adventitial NAD(P)H oxidase components, which can be normalized by AT1 receptor blockade.
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Losartan normalization of adventitial oxidase supports AT1-mediated mechanism; hypothesis-generating for human hypertension therapies.
Cifuentes-Pagano et al. (2000) studied Angiotensin II-dependent hypertension. Angiotensin II infusion vs. Sham infusion was evaluated on Vascular levels of O(2)(-) and NAD(P)H oxidase subunits. Angiotensin II infusion in mice increased systolic blood pressure and aortic superoxide levels due to heightened adventitial NAD(P)H oxidase subunit expression, which was normalized by losartan.
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