Why the study?
Does Angiotensin II regulate NAD(P)H oxidase expression and superoxide formation in human endothelial cells, and does AT1 receptor blockade reduce this expression in patients with coronary artery disease?
Population
Human endothelial cells and internal mammary artery biopsies from patients with coronary artery disease…
Design
Preclinical
Authors
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AT1 blockade may reduce vascular oxidative stress; hypothesis-generating and should not yet change practice in CAD.
Does Angiotensin II regulate NAD(P)H oxidase expression and superoxide formation in human endothelial cells, and does AT1 receptor blockade reduce this expression in patients with coronary artery disease?
Angiotensin II induces proatherosclerotic oxidative stress via NAD(P)H oxidase in human endothelial cells, which can be mitigated by AT1 receptor blockade.
Rueckschloss et al. (2002) studied this question.
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