What does this research mean for the field?

Angiotensin II mediates its physiological and pathophysiological effects on vascular tissue largely by activating NAD(P)H oxidases to produce reactive oxygen species, which subsequently drive redox-mediated events linked to vascular pathologies. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review aims to elucidate how angiotensin II signaling leads to reactive oxygen species production and its implications for vascular health.

December 1, 2002Antioxidants and Redox Signaling

NAD(P)H Oxidase-Derived Reactive Oxygen Species as Mediators of Angiotensin II Signaling

View Full Paper

Ask AI

Bookmark

Design

Review

Authors

IHIbrahim R. HannaLiverpool Hospital YTYoshihiro TaniyamaKansai Medical University KSKatalin SzöcsUniversität Hamburg

Discussion

Member takes

Implication

May support NAD(P)H oxidase inhibition in hypertension and atherosclerosis; leaves open need for clinical trials.

Key Points

This review aims to elucidate how angiotensin II signaling leads to reactive oxygen species production and its implications for vascular health.
Comprehensive literature review on angiotensin II signaling and NAD(P)H oxidase functions
Focus on the molecular mechanisms linking angiotensin II to oxidative stress
Examine the relationship between reactive oxygen species and vascular pathologies.
Angiotensin II activates NAD(P)H oxidases, leading to increased reactive oxygen species production.
Reactive oxygen species contribute to vascular conditions such as hypertension and atherosclerosis.
Provides insights into potential targets for therapeutic interventions related to oxidative stress in vascular diseases.

Cite This Study

Hanna et al. (2002) studied this question.

synapsesocial.com/papers/6a1be8fbfc87fd06169cea7a https://doi.org/10.1089/152308602762197443

View Full Paper

Ask AI

Bookmark

NAD(P)H Oxidase-Derived Reactive Oxygen Species as Mediators of Angiotensin II Signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

NAD(P)H Oxidase-Derived Reactive Oxygen Species as Mediators of Angiotensin II Signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider