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October 8, 2025

The dominant follicle: the final frontier in bovine oocyte development.

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Authors

LLLaís Barbosa LatorracaUniversity College DublinAGAntónio GalvãoUniversity of LondonJDJ. D’augeroUniversity College Dublin

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Overview

Research reveals key gene expression changes in oocytes from dominant follicles, suggesting improved ART methods for cattle.

Key Points

  • Oocytes from dominant follicles exhibit superior maturation capabilities, essential for successful fertilization.
  • Blastocyst rates after IVF remain lower for in vitro-matured oocytes (~35%) compared to in vivo counterparts (58-78%).
  • RNA sequencing unveiled crucial shifts in transcripts associated with energy metabolism during oocyte capacitation.
  • Enhancing the maturation environment to reflect natural conditions could significantly boost reproductive efficiency in cattle.

Cite This Study

Latorraca et al. (2025) studied this question.

synapsesocial.com/papers/68e6d7971ffa7aa7d63d15ddhttps://doi.org/10.1590/1984-3143-ar2025-0071
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 17 Role of the preovulatory follicle in oocyte metabolic and developmental competence for pregnancy2024
  2. 2Decoding molecular features of bovine oocyte fate during antral follicle growth via single-cell multi-omics analysis2024 · 3 citations
  3. 3Approaches to in vitro oocyte growth in domestic farm mammals: how and why?2025
  4. 4Follicle Size Regulates Cytoplasmic Maturation, Lipid Content, and Embryo Cryosurvival in Bovine Oocytes Matured In‐Vitro2026
  5. 5Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth2024 · 8 citations