What type of study is this?

This is a Experimental Study study.

October 8, 2025

Improved Syntheses, Crystal Structures Analysis, DFT Calculation, Anticancer and Antibacterial Properties of Some 4‑(Benzylamino)benzoic Acid Derivatives.

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Authors

AHAhmed K. Hijazi QSQusai M. Sarayrah AMAbdelrahman W. Malkawi

Discussion

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Overview

Synthesis of benzylamino benzoic acid derivatives showed antibacterial effects and promising anticancer activity, indicating potential therapeutic applications.

Key Points

Several derivatives demonstrate moderate antibacterial activity, with minimum inhibitory concentration ranging from 64 to 128 μg/mL against various bacterial strains.
Compound 18 exhibited anticancer activity with IC50 values of 90.69 μM against Non-Small Cell Lung Cancer and 32.22 μM against Small Cell Lung Cancer.
Crystal structures were confirmed using advanced techniques, including X-ray diffraction, identifying key intermolecular interactions critical for compound stability.
Quantum chemical calculations provided insights into the electronic properties of compounds, contributing to the understanding of their biological activity.

Cite This Study

Hijazi et al. (2025) studied this question.

synapsesocial.com/papers/68e6d7971ffa7aa7d63d15e4 https://doi.org/10.1021/acsomega.5c03898

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October 8, 2025

Improved Syntheses, Crystal Structures Analysis, DFT Calculation, Anticancer and Antibacterial Properties of Some 4‑(Benzylamino)benzoic Acid Derivatives.

View Full Paper

Ask AI

Bookmark

Authors

AHAhmed K. Hijazi QSQusai M. Sarayrah AMAbdelrahman W. Malkawi

Discussion

Member takes

Overview

Synthesis of benzylamino benzoic acid derivatives showed antibacterial effects and promising anticancer activity, indicating potential therapeutic applications.

Key Points

Several derivatives demonstrate moderate antibacterial activity, with minimum inhibitory concentration ranging from 64 to 128 μg/mL against various bacterial strains.
Compound 18 exhibited anticancer activity with IC50 values of 90.69 μM against Non-Small Cell Lung Cancer and 32.22 μM against Small Cell Lung Cancer.
Crystal structures were confirmed using advanced techniques, including X-ray diffraction, identifying key intermolecular interactions critical for compound stability.
Quantum chemical calculations provided insights into the electronic properties of compounds, contributing to the understanding of their biological activity.

Cite This Study

Hijazi et al. (2025) studied this question.

synapsesocial.com/papers/68e6d7971ffa7aa7d63d15e4 https://doi.org/10.1021/acsomega.5c03898

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