What type of study is this?

This is a Experimental Study study.

October 8, 2025

PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.

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Authors

RLR. LuRAND Corporation LRLingling RenLishui City People's Hospital XFXiaobin FeiJiangyin People's Hospital

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Implication

This analysis demonstrates PSMD14 upregulates ACLY expression via LDHA deubiquitination, suggesting metabolic pathways are crucial in pancreatic cancer progression.

Key Points

Increased ACLY expression promotes lipid biosynthesis, driving pancreatic cancer progression.
PSMD14 stabilizes LDHA through its deubiquitinase activity, leading to elevated lactate levels.
Targeting PSMD14 and lactylation in therapeutic strategies may suppress pancreatic tumor growth.
Histone lactylation mediated by lactate enhances lipid metabolic pathways in tumor cells.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/68e6d7971ffa7aa7d63d15f2 https://doi.org/10.1002/advs.202505762

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Implication

This analysis demonstrates PSMD14 upregulates ACLY expression via LDHA deubiquitination, suggesting metabolic pathways are crucial in pancreatic cancer progression.

PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.

Discussion

Member takes

Implication

Key Points

Cite This Study

PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.

Discussion

Member takes

Implication

Key Points

Cite This Study

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