Continuous flow method improves substrate scope and functional group tolerance, indicating better optimization techniques.
We report the development of a continuous flow approach to nitrogen atom insertion. The setup is modular, enabling the rapid optimization of reaction conditions for a wide range of substrates. The milder reaction conditions led to an improved substrate scope and functional group tolerance compared to batch conditions. The reactions can also be safely scaled up to preparative scale.
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Moon et al. (2025) studied this question.
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