Interaction between the sphingolipid membrane rafts and the concentration of the amyloid complex and analyses

Abstract Amyloidosis diseases are a heterogeneous group of pathologies that have a strong impact on current society both in global health and in the economic system of each country. The analysis of how the entry of the toxic species identified into the amyloid oligomeric elements occurs is the main objective of much research in the sector. In this work, we analyze a hypothesis of the entry of oligomers into the membrane whereby, after a massive recruitment of the sphingolipid rafts thanks to their connection with the oligomers, a cleansing of the membrane itself occurs. This pathological event creates a sort of pore which, subsequently stabilized, allows the oligomers to enter the cell. In this work, we build an entry model based on dynamic networks that investigates the fundamental mechanisms that lead to the entry of amyloid oligomers into the cell after having formed a critical concentration in the oligomer-membrane complex which, thanks to the conformational changes affecting the oligomers themselves, carries out the cleansing of the membrane and the entry of these pathogenic elements. The global dynamic network is divided into subnetworks which are expressed by algorithms that identify both time and threshold concentration as the fundamental moment in triggering the entire pathological process.