Diagnostic evaluation demonstrates clinical criteria identify predominant vascular pathology in cognitive impairment, indicating effective differentiation from mixed amyloid disease.
There are major challenges in determining the etiology of vascular cognitive impairment (VCI) clinically, especially in the presence of mixed pathologies, such as vascular and amyloid. Most recently, two criteria (American Heart Association/American Stroke Association (AHA/ASA) and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)) have been proposed for the clinical diagnosis of VCI but have not as yet been validated using neuroimaging.
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Folloso et al. (2024) studied this question.
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