Role of Non-Coding RNAs in Gene Regulation in Brazil

Purpose: The aim of the study was to examine the role of non-coding RNAs in gene regulation in Brazil Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: The study found that non-coding RNAs (ncRNAs) play diverse and pivotal roles in gene regulation across various biological processes. From microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) to circular RNAs (circRNAs) and transfer RNA-derived fragments (tRFs), ncRNAs participate in fine-tuning gene expression at multiple levels, including transcriptional and post-transcriptional regulation. These molecules act as crucial regulators of cellular homeostasis, development and disease pathogenesis. Unique Contribution to Theory, Practice and Policy: Central dogma of molecular biology & competitive endogenous rna (cerna) hypothesis may be used to anchor future studies on role of non-coding RNAs in gene regulation in Brazil. Leveraging the dysregulated expression of non-coding RNAs as diagnostic and prognostic biomarkers will facilitate the development of personalized therapeutic strategies. By targeting specific non-coding RNAs associated with disease states, clinicians can tailor treatment regimens to individual patients, improving efficacy and minimizing adverse effects. Policymakers should prioritize funding for non-coding RNA research, recognizing its significance in advancing biomedical knowledge and improving healthcare outcomes. Educational institutions and professional organizations should incorporate non-coding RNA biology into undergraduate and graduate curricula, as well as continuing education programs for healthcare professionals.