0413 Exploring the Efficacy of Cannabinol in Sleep Enhancement: A Breakthrough in Non-Intoxicating Solutions

Introduction Sixty percent of Americans report getting less than the recommended seven hours of nightly sleep. Poor sleep is a public health concern linked to many health issues, including inflammatory conditions, obesity, heart disease and reduced quality of life. As consumers seek natural, safe alternatives for better sleep, the introduction of a non-intoxicating hemp-derived cannabinoid solution presents an attractive option. Methods Conducting the first-ever double-blind, randomized, placebo-controlled trial, an independent clinical research company examined the effects of TruCBN, FloraWorks proprietary ultra pure CBN on sleep patterns. The trial involved over 1,000 participants at least 21 years old from across the US, comparing the outcomes of CBN to melatonin and a placebo. There were three CBN groups, one melatonin group and one placebo group, as follows: CBN groups: 25 mg, 50 mg, 100 mg Melatonin: 4 mg Control: placebo Results - The group taking 50 mg of CBN showed significant sleep improvements compared to placebo, and most of the group experienced a clinically important improvement. - The group taking 4 mg melatonin also showed significant sleep improvements compared to the placebo. - The group taking 50 mg of CBN had slightly better sleep improvements compared to 4 mg of melatonin. - The groups taking 25 mg and 100 mg of CBN had marginally significantly better sleep improvements compared to placebo. - All three tested doses of CBN are statistically equivalent to one another, and statistically equivalent to 4 mg melatonin, for improving sleep quality. All three doses of CBN show a Minimal Clinically Important Difference (MCID) with respect to placebo. - All side effects were mild or moderate. There were no significant differences in the frequency of reported side effects between any dose of CBN or melatonin compared to placebo. Conclusion Beyond illuminating CBN's efficacy in enhancing sleep, this research positions it as a formidable player in the pursuit of superior sleep aids, disrupting the conventional over-the-counter sleep aid market. The discovery that CBN is at least as effective as melatonin for improving sleep is particularly promising, especially given the side effects of melatonin and the growing concerns surrounding children consuming melatonin beyond recommended limits. Support (if any)