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Synapse
April 19, 2024

Genomic and proteomic evidence for hormonal and metabolic foundations of polycystic ovary syndrome

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Authors

LMLoes M E MoolhuijsenJZJia ZhuBMBenjamin H. Mullin

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Overview

Genetic and proteomic study reveals hormonal and metabolic drivers in polycystic ovary syndrome, suggesting balanced pleiotropic fertility effects alongside life-long cardio-metabolic risks.

Key Points

  • Risk-increasing loci for polycystic ovary syndrome expand from 19 to 29, identifying 31 associated plasma proteins linked to delayed menopause.
  • Genetic and proteomic analysis reveals that a polygenic risk score associates with adverse cardio-metabolic outcomes across both sexes.
  • Findings highlight how polycystic ovary syndrome susceptibility confers balanced pleiotropic effects on fertility despite metabolic consequences.

Cite This Study

Moolhuijsen et al. (2024) studied this question.

synapsesocial.com/papers/68e6e657b6db6435876614c5https://doi.org/10.1101/2024.04.18.24306020
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