Trial protocol demonstrates bilateral stereoelectroencephalography electrode implantation in treatment-resistant depression, highlighting personalized closed-loop neuromodulation.
Treatment-resistant depression is a leading cause of disability. Our center's trial for neurosurgical intervention for treatment-resistant depression involves a staged workup for implantation of a personalized, closed-loop neuromodulation device for refractory depression. The first stage ("stage 1") of workup involves implantation of 10 stereoelectroencephalography (SEEG) electrodes bilaterally into 5 anatomically defined brain regions and involves a specialized preoperative imaging and planning workup and a frame-based operating protocol.
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Starkweather et al. (2024) studied this question.
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