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April 19, 2024Synthetic and Systems BiotechnologyOpen Access

Rational engineering of homospermidine synthase for enhanced catalytic efficiency toward spermidine synthesis

Wenjing Liu Xiaoxiang Hu Yi Yan Yujie Cai

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Abstract

Spermidine is a naturally occurring polyamine widely utilized in the prevention and treatment of various diseases. Current spermidine biosynthetic methods have problems such as low efficiency and complex multi-enzyme catalysis. Based on sequence-structure-function relationships, we engineered the widely studied homospermidine synthase from

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Cite This Study

Liu et al. (2024) studied this question.

synapsesocial.com/papers/68e6e66db6db643587661eed https://doi.org/10.1016/j.synbio.2024.04.012

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