Overexpression of ACVRL1 inhibits the tube formation ability of HMEC-1 endothelial cells

Introduction HHT type 2 (HHT2) is an autosomal dominant inherited disease in which one allele of the ACVRL1 gene is mutant. Patients have severe disturbances in angiogenesis and clinically often present with severe nosebleeds and an impaired quality of life. The aim of our study was to investigate how overexpression of ACVRL1 in the endothelial cell line HMEC-1 affects angiogenesis.