Intracochlear distribution and accumulation of locally applied Dexamethasone formulations in a large animal model

Introduction Currently, glucocorticoids are commonly used as treatment for a multitude of inner ear disorders. Large animal models with human-like inner ear dimensions can provide valuable insights into intracochlear pharmacokinetics, deepening our understanding of how drugs propagate within the cochlea. In a translational research approach, we topically applied dexamethasone (DEX) to the middle and inner ears of piglets and analyzed its distribution in the porcine cochlea.