Development of anti-mHsp70 CAR cells targeting HNSCC tumors

Introduction Chimeric antigen receptors (CAR) consisting of an extracellular anti-body based single chain variable fragment (scFv) linked to a transmembrane and intracellular signaling domain can boost anti-tumor activities of effector cells. In this study, we focused on membrane-bound heat shock protein 70 (mHsp70) as a tumor specific target for the recognition by an anti-mHsp70 CAR in NK cell lines. We focused on targeting HNSCC tumors, due to limited treatment options available for late-stage tumors.