Phage predation, disease severity, and pathogen genetic diversity in cholera patients

Naïma Madi; Emilee Cato; Md. Abu Sayeed; Ashton Creasy-Marrazzo; Aline Cuénod; Kamrul Islam; Md. Imam Ul Khabir; Taufiqur Rahman Bhuiyan; Yasmin Ara Begum; Emma Freeman; Anirudh Vustepalli; Lindsey Brinkley; Manasi Kamat; Laura S. Bailey; Kari B. Basso; Firdausi Qadri; Ashraful Islam Khan; B. Jesse Shapiro; Eric J. Nelson

doi:10.1126/science.adj3166

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Abstract

Despite an increasingly detailed picture of the molecular mechanisms of bacteriophage (phage)-bacterial interactions, we lack an understanding of how these interactions evolve and impact disease within patients. In this work, we report a year-long, nationwide study of diarrheal disease patients in Bangladesh. Among cholera patients, we quantified

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Madi et al. (2024) studied this question.

synapsesocial.com/papers/68e6e76cb6db64358766349f https://doi.org/10.1126/science.adj3166

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Phage predation, disease severity, and pathogen genetic diversity in cholera patients

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Phage predation, disease severity, and pathogen genetic diversity in cholera patients

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