Fungal infections have been a serious problem since long time. However, development of new antifungals has improved the situation and helped a lot in overcoming the problems caused due to invasive fungal infections. It is very crucial to understand the mechanism behind fungal infections and generation of resistance. Extensive use of azole antifungals has caused their resistance leading to medication failure. Focus on antimicrobials got a boom after Covid 19 outbreak but still fungal infections are least focused. Fluconazole a widely used antifungal have no action against Candida albicans. Due to excessive use resistance have been created this reason warns us that there is a great need to introduce new and better antifungals in the market. Beside this new antifungal like Echinocandin and second generation of triazole antifungals are clinically important. On the top of this Posaconazole (triazole second generation) is the azole active against Zygomycete fungi. Combination therapy is an additional method for treating invasive fungal infections. However, in the end, there is a mismatch between the supply and demand for antifungals.an additional method for treating invasive fungal infections. Hence need to introduce novel antifungals have become very important. The main aim of this article is to focus on the emerging fungal infections and mechanism of resistance along with study of fluconazole as antifungal agents.
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Joshi et al. (2024) studied this question.
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